Studies

Cancer Type: Various Solid Tumors

Treatment ModalityReferenceLevel of EvidenceGuideline
Chemotherapy (5-FU bolus i.v)IIRecommendation: that patients receiving bolus 5-FU chemotherapy undergo 30-min oral cryotherapy to prevent oral mucositis

Cancer Type: Hematologic Cancers

Treatment ModalityReferenceLevel of EvidenceGuideline
Haematopoietic stem cell transplantation HSCT) with or without total body irradiation. Chemotherapy(Melphalan)IIISuggestion to use cryotherapy to prevent oral mucositis in patients receiving high-dose melphalan, with or without total body irradiation, as conditioning for HSCT

Cancer Type: Various (excluding Head and Neck)

Treatment ModalityReferenceLevel of EvidenceGuideline
Chemotherapy(Various)IISuggestion to use cryotherapy for mucositis prevention

Cancer Type: Colon Cancer

Treatment ModalityReferenceLevel of EvidenceGuideline
Chemotherapy (Leucovorin/ 5-FU)IIISuggestion to use allopurinol ice balls during chemotherapy

Cancer Type: Various solid tumors (including lung)

Treatment ModalityReferenceLevel of EvidenceGuideline
Chemotherapy (Etoposide, Platinol, Mitomycin, Vinblastin)ISuggestion to place ice cubes in mouth 5 mins before, during, and till end of IV infusion chemotherapy

Cancer Type: Gastrointestinal cancer

Treatment ModalityReferenceLevel of EvidenceGuideline
Chemotherapy(Leucovorin. 5-FU)ISuggestion to place ice cubes in mouth 5 mins before, during, and till end of IV infusion chemotherapy

Cancer Type: Various solid tumors

Treatment ModalityReferenceLevel of EvidenceGuideline
Chemotherapy (5-FU continuous infusion i.v.)IIINo guideline possible

Cancer Type: Various solid tumors

Treatment ModalityReferenceLevel of EvidenceGuideline
Chemotherapy (edatrexate i.v.)(investigational drug)IIINo guideline possible