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How The Chemo Mouthpiece Works

The Science Behind Chemo Mouthpiece

Chemo Mouthpiece builds upon an existing type of treatment – cryotherapy – which uses cold temperatures to alter the body’s condition. It’s the same technique that brought ice chips and popsicles to hospitals and infusion centers: applying near-freezing temperatures to the tissues of the mouth forces the blood vessels in those tissues to shrink, reducing circulation and allowing less of the chemotherapy drugs to reach the mouth.

with chemo mouthpiece watch video - How it Works

This phenomenon, called vasoconstriction, has proven effective at restricting toxic drugs’ access to vulnerable, healthy tissues in the oral cavity. The ice chips handed out by doctors and nurses work on this principle, but their effects are inconsistent. They also cause nausea and are intolerable for those with sensitive teeth.

Because the ice chips sit on the bottom of the mouth, with little to no contact with the upper palate or cheeks, they are only partially effective; ice pops suffer from a similar issue, and mouthwashes can only treat the symptoms once they appear, offering little in terms of preventative care.

Enter Chemo Mouthpiece. Essentially, this device acts as an ice pack for your mouth – unlike ice chips or popsicles, however, it uniformly cools the entire oral cavity. This important distinction makes it uniquely suited to mitigate the symptoms of oral mucositis. Simply use the device while receiving an infusion of chemotherapy medication to cool the entire oral cavity and stem the flow of harmful chemicals into the area.

img thermographic scans - How it Works

Thermographic scans of patients using the mouthpiece have shown average temperature changes of 31.3°F over the course of 30 minutes.

img mouth 1 - How it Works
img mouth 2 - How it Works
img mouth 3 - How it Works
img mouthpiece as seen on tv 1 - How it Works

Learn how to properly use the Chemo Mouthpiece in this instructional video. You may also scroll down for more information regarding cleaning and care.

cmp vid4 - How it Works

Instructions For Use

  1. Prior to first use, place unit in unopened double sealed packaging in the freezer for a minimum of 6 hours.
  2. When center blue core is frozen solid, unit is ready for use.
  3. Just prior to use, remove unit from packaging and slide base into insulated sleeve. Save the resealable bag for future storage.
  4. Fit mouthpiece chamber into mouth and place your lips over the outer edge.
  5. Once inserted, squeeze the insulated sleeve/base to circulate cold water inside the mouthpiece.
  6. Tilt head back while in use, unit has breathing tubes to facilitate normal breathing.
  7. Continue to squeeze insulated sleeve/base every few minutes to keep circulating cold water.


After use, remove the insulated sleeve and clean the mouthpiece with soap and water. Use the supplied cleaning brush to clean inside the breathing tubes with soap and hot water.

After cleaning, allow the unit to dry and place back into the resealable bag and store in the freezer. The mouthpiece must be refrozen within 24 hours after use and must always be stored in the freezer.

The unit is ready for use anytime for up to 2 years if stored properly in a standard freezer.

img 2 mouthpieces 1 with sleeve - How it Works